高光谱成像用于系统性硬化症皮肤评估：一项初步研究

摘要：高光谱成像 (HSI) 是一种从经皮空间和光谱信息中获取定量测量的新技术。在 SSc 患者中，皮肤紧绷的严重程 度与内部器官受累有关。然而，使用改良的 Rodnan 皮肤评分进行临床评估变化很大，目前没有通用的标准化协议。本 研究旨在比较使用皮肤评分、超声和 HSI 区分 SSc 患者和健康对照的能力。方法。利用短波红外光检测 HSI 的光谱角 映射器 (SAM)。此外，通过皮肤评分、超声检测真皮厚度和应变弹性成像评估皮肤严重程度。Spearman 相关性用于评估 皮肤评分、应变比、厚度和 SAM。通过受试者工作特征曲线对各种评估工具进行比较。结果。总共招募了 31 名 SSc 患 者。SAM 与皮肤评分和真皮厚度呈正相关。在皮肤评分正常的系统性硬化症患者中，SAM 值仍显著高于健康对照组。 与皮肤评分（（ AUC：0.712，P<0.001）、厚度（（ AUC：0.585，P=0.009）和弹性成像应变比（（ AUC：0.522，P=0.510）相比， SAM 在检测系统性硬化症时表现出最高的曲线下面积（（ AUC：0.812，P<0.001）。此外，皮肤紧绷的严重程度通过光谱图 中波形的增量变化反映出来。结论。SAM 与皮肤评分相关，并且足够敏感以检测亚临床疾病。HSI 可用作评估系统性硬 化症皮肤变化的一种新型非侵入性方法。

关键词：短波红外、高光谱成像、系统性硬化症、皮肤厚度、超声、弹性成像、应变比

期刊：Rheumatology

DOI：10.1093/rheumatology/keaa067

设备：GaiaField

Hyperspectral imaging for skin assessment in systemic sclerosis: a pilot study

Abstract：Objective. Hyperspectral imaging (HSI) is a novel technology for obtaining quantitative measurements from trans cutaneous spatial and spectral information. In patients with SSc, the severity of skin tightness is associated with in ternal organ involvement. However, clinical assessment using the modified Rodnan skin score is highly variable and there are currently no universal standardized protocols. This study aimed to compare the ability to differentiate be tween SSc patients and healthy controls using skin scores, ultrasound and HSI. Methods. Short-wave infrared light was utilized to detect the spectral angle mapper (SAM) of HSI. In addition, skin severity was evaluated by skin scores, ultrasound to detect dermal thickness and strain elastography. Spearman’s correlation was used for assessing skin scores, strain ratio, thickness and SAM. Comparisons of vari ous assessment tools were performed by receiver operating characteristic curves. Results. In total, 31 SSc patients were enrolled. SAM was positively correlated with skin scores and dermal thick ness. In SSc patients with normal skin scores, SAM values were still significantly higher than in healthy controls. SAM exhibited the highest area under the curve (AUC: 0.812, P <0.001) in detecting SSc compared with skin scores (AUC: 0.712, P<0.001), thickness (AUC: 0.585, P¼0.009) and strain ratio by elastography (AUC: 0.522, P¼0.510). Moreover, the severity of skin tightness was reflected by the incremental changes of waveforms in the spectral diagrams. Conclusion. SAM was correlated with skin scores and sufficiently sensitive to detect subclinical disease. HSI can be used as a novel, non-invasive method for assessing skin changes in SSc.

Keywords：short-wave infrared, hyperspectral imaging, systemic sclerosis, skin thickness, ultrasound,elastography, strain ratio